Endocrine Abstracts

We assessed whether the hypothalamic-pituitary-adrenal (HPA) axis is affected after withdrawal of oral steroids in patients who have been on steroids for at least ten years. Recent advances in treatment of patients with severe asthma with inhaled fluticasone propionate, and the use of steroid sparing drugs such as methotrexate has allowed the withdrawal of long term oral steroids in patients who otherwise had steroid dependant disease.We performed a 250 ...

Introduction: Autism is a neurodevelopmental disorder (NDD). It manifests itself in early childhood, with varying degrees of impact on the child’s developmental spheres. Although the underlying mechanisms have yet to be elucidated, ASD is considered to be multifactorial, with both genetic and non-genetic risk factors. Is there an established link between diabetes and autism?Observation: This is a 16-year-old child with no maternal history of hypergl...

Background: Pituitary metastases are a rare occurrence, accounting for just 0.4% of intracranial metastatic tumours and are most often associated with breast and lung malignancies. The vast majority of lesions are asymptomatic and due to the predilection of metastasis to the posterior lobe of the pituitary gland, clinical presentation with anterior pituitary insufficiency is uncommon and rarely reported in literature.Case summary: A 51-year old male with...

Subclinical hypothyroidism (SCH) represents a mild or compensated form of primary hypothyroidism. Although the relationship between SH and lipid profile have been reported in several studies, the results are conflicting. The objective of the present study is to assess dyslipidemia among patients with SCH. Our study included 107 patients vs 108 sex matched controls. Clinical information and medical history were obtained through a questionnary from all SCH patients and normal co...

Background and Objectives: Fasting causes a major change in the dietary habits including the frequency, the timing, and the patterns which will result in a major change in the metabolic response of the body. Physicians should advise the patients about the complications of diabetes mellitus during fasting especially hypoglycemia, the aim of this study is to determine the relation between type 2 diabetes mellitus and hypoglycemia and to evaluate whether this correlation is signi...

Background: Obesity is a serious health problem worldwide and is caused by a wide variety of etiologies. There are several hormones which have been proved to be associated with increased body weight and has a direct effect on the fat metabolism like thyroid hormones.Methods: This is a case control study which included 384 adult persons, they were divided into 2 groups according to the thyroid function status, the first group included 204 apparently healt...

Chronic administration of L thyroxine to children with hypothyroidism may affect cardiovascular dynamics.Aim of the study: We measured the BP and heart rate (HR) of 25 randomly selected children with hypothyroidism in relation to their serum free T4, and TSH levels and thyroxine dose mg/kg. Methods: 25 randomly selected children with a mean age 9.6 +/- 4.5 years with the diagnosis of congenital or acquired hypothyroidism. They were...

Long-term exposure to cortisol carry health risk and its important to establish the cause and exclude exogenous steroid use before starting investigation for endogenous causes, we present a young man with clinical picture of Cushing but low random cortisol.16 years old studying for his AS examinations at the time, presented to his GP with 5-week history of fatigue, weight gain of 2 stone in 18 months, insomnia, diarrhoea, left ...

Method: We carried out a retrospective audit of baseline data for patients under our care with primary hyperparathyroidism on cinacalcet therapy, against the NHS England Clinical Commissioning Policy (July 2016). Patients with secondary hypercalcaemia due to end stage renal failure were excluded.Results: 40 patients were identified, 9 men and 31 women, with an age range of 32–89 years (median age 78). 3 patients were under 50 ...

Long-term exposure to cortisol carry health risk and its important to establish the cause and exclude exogenous steroid use before starting investigation for endogenous causes, we present a young man with clinical picture of Cushing but low random cortisol.16 years old studying for his AS examinations at the time, presented to his GP with 5-week history of fatigue, weight gain of 2 stone in 18 months, insomnia, diarrhoea, left ...